Immune response in DM1 has also been explored at systemic level: higher levels of the soluble tumor necrosis factor receptor 2 (sTNFR2), interleukin (IL) 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and IL-6, as well as decreased levels of IL-10 have been found in the plasma of patients, compared to healthy subjects. Here, TNF is linked to myotonic dystrophy type 1.