In fact, numerous mis-splicing events have been described in genes expressed in DM1 brain tissues implicated in its CNS symptomatology, including GRIN1/NMDAR1 exons 5 and 21, MAPT exons 2–3, 10, APP exon 8, MBNL1/2 exon 7, CAMK2D exons 14–15, and SORBS exon 26 [14,26,27]. This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.