CXCL8 and major depressive disorder: Consistent with this notion, several studies have linked CNS pathology with altered levels of chemokines: CXCL10 has been implicated with altered cognitive function [60,61], and neuroendocrine dysregulation [62]; furthermore, altered levels of CXCL8 were found to be associated with schizophrenia [63], and depression [64], as well as with structural brain abnormalities [65].