MSH6 and sebaceous gland neoplasm: Indeed, most of sebaceous MSI/dMMR tumors display a loss of MSH2 and MSH6 proteins, which is widely considered as highly predictive of LS, but a MSH2 germline mutation is detected in only one-third of cases [92,94,244], suggesting that a significant proportion of MSI/dMMR sebaceous tumors are sporadic.