MRC1 and hyperinsulinemic hypoglycemia, familial, 4: Furthermore, a high rate of MMR deficiency in LS-associated adenomas (around 70–80%) [157,160,166,167], the complete and homogeneous loss of MMR protein expression in a majority of adenomas, and the rarity of adenomas with a focal loss of MMR proteins (3% in Ahadova et al. [160]) suggest that the MMR system is involved in the initial development of the adenoma as an early event.