Buchanan et al. combined the results of three different colorectal cancer cohorts and determined that LLS represents 59% (95% CI: 55–64%) of the patients with a MSI/dMMR CRC tested for germline MMR gene variations (433 patients in total after the exclusion of tumors with MLH1 hypermethylation) [232]. The gene discussed is MLH1; the disease is colorectal carcinoma.