Moreover, in a recent study, the tumor sequencing of MMR genes among other genes, in addition to assessing the BRAF and MSI status in a series of patients with CRC, showed better sensitivity than MSI or IHC, followed by a BRAF mutation analysis (100% vs. 89.7%), with equal specificity (95.3% vs. 94.6%) for the identification of LS [297]. This evidence concerns the gene BRAF and neoplasm.