BRAF and colorectal carcinoma: Several studies suggested a very high sensitivity and high specificity of V600E-specific IHC for the detection of BRAF-mutated CRC [276,277,278] (sensitivity, 100% and specificity, 98.8–100%), while others pointed out insufficient sensitivity, specificity, and robustness for the use in clinical practice (sensitivity, 51–85% and specificity 68% [279] and sensitivity, 35–71% and specificity, 74% [280]).