Overall mortality was associated with age (HR 1.02, p = 0.01), diabetes mellitus (HR 2.01, p < 0.01), systolic blood pressure (SBP) >140 mmHg (HR 1.78, p = 0.04), hemoglobin levels above median (HR 0.57, p = 0.03), and erythropoietin dose above the median (HR 1.94, p = 0.01) in the univariate analysis (Table 4). The gene discussed is EPO; the disease is diabetes mellitus.