Recently, variations in a few genes have been described in OAVS patients, including de novo changes in the myelin transcription factor 1 (MYT1) gene, involved in the retinoic acid metabolism, [22,23] and in the AMIGO2 and ZYG11B genes, the former participating to the (PI3K)/AKT signaling pathway [24], and the latter involved in proteasome degradation [25]. The gene discussed is ZYG11B; the disease is craniofacial microsomia.