SOD1 and metabolic dysfunction-associated steatotic liver disease: As already mentioned, OxS is linked to the pathogenesis of NAFLD, and this has been observed in experimental models of NAFLD/NASH [9] as well as in NAFLD patients who have an impaired redox balance, demonstrated by decreased levels of hepatic glutathione and anti-oxidant enzymes such as SOD and catalase [5,57].