WHRN and cancer: Wi-N and Wi-A have been reported to have anticancer activities that works through the inhibition of Mortalin-p53 interactions leading to activation of tumor suppressor activities of p53, downregulation of NFkB leading to inhibition of inflammation signaling, inhibition of MRN complex leading to accumulation of DNA damage and growth arrest of cancer cells and inhibition of VEGF and MMPs leading to inactivation of cancer cell migration and metastasis [27,28,29,30,31,32,33,34,35,36].