Analyzing genes encoding enzymes involved in the synthesis or the degradation of endocannabinoids (FAAH, MAGL, DAGL, and NAPE-PLD), we found that any available studies described the association of MAGL and DAGL polymorphism and their role in the incidence of obesity, whereas FAAH was defined as an obesity-related factor. Here, MGLL is linked to obesity due to melanocortin 4 receptor deficiency.