Regarding human studies, OMC can modulate thyroid hormone receptor (THR) in human hepatocarcinoma cell lines (HepG2) [30] and is a deiodinase-disrupting chemical since it alters the expression of related genes (e.g., type II iodothyronine deiodinase (DIO2)) as reported by Song, et al. in human neuroblastoma cells [31]. The gene discussed is DIO2; the disease is neuroblastoma.