CD8A and neoplasm: When they transfected the CD8+ T cells with a miR-149-3 mimic, they noted a reversal of T cell exhaustion with increased secretion of effector cytokines (i.e., TNF-α, IFN-γ, interleukin (IL)-2) leading to tumor cell killing in vitro, rendering this miRNA a potential candidate for therapeutic interventions [100].