Cobomarsen has potent activity against mycosis fungoides [79] and diffuse-large B cell lymphoma (DLBCL) [80] cells in vitro as it leads to decreased cell proliferation and increased apoptosis via inhibition of multiple signaling pathways including JAK/STAT, PI3K/AKT and MAPK. The gene discussed is AKT1; the disease is diffuse large B-cell lymphoma.