The MSC risk level (intermediate/low versus high, H: 0.35, p = 0.0026), PD-L1 expression on tumor cells (≥50% versus <50%, H: 0.35, p = 0.0006) and combined MSC and PD-L1 score (1–2 favorable markers versus 0 favorable markers, H: 0.25, p = 0.0006) remained independently associated with PFS in multivariate analysis. This evidence concerns the gene CD274 and neoplasm.