IFIH1 and infection: Virus infection experiments in RIG-I and/or MDA5 gene-edited cells revealed that RIG-I senses a variety of negative-strand RNA viruses (e.g., influenza (IAV) and vesicular stomatitis viruses (VSV)) as well as some herpesviruses (for example, herpes simplex virus-1 (HSV-1), Epstein–Barr virus (EBV), and Kaposi’s sarcoma herpesvirus (KSHV)), while MDA5 detects infection by picornaviruses and coronaviruses [6,7].