CXCL10 and Mental deterioration: Moreover, Blank et al. showed that the production of CXCL10 by brain endothelial and epithelial cells was associated with diminished hippocampal plasticity, and that CXCR3−/− and CXCL10−/− mice retained better memory and learning functions [89], supporting the notion that inflammatory factors could have a role in cognitive decline.