Of these twelve proteins, 10 were rescued by 414: six unique to Tg animals (GJA1, EEF1A1, IDH1, SGTB, PIN1, RHEB) and four proteins that are shared across both late AD (human and Tg) datasets: PACSIN1, GJA1, VSNL1 and NDUFB5 (Figure 6C). The gene discussed is IDH1; the disease is Alzheimer disease.