RIPK1 and tauopathy: The targets of 414 include kinases involved in tauopathy pathogenesis, including protein kinase R-like endoplasmic reticulum kinase or PERK [10,11,12], the mitogen-activated protein kinase, or MAPK, cascade [10], receptor-interacting serine/threonine-protein kinase 1 or RIPK1 [17] and the receptor tyrosine kinase, KIT [18].