TNFRSF9 and neoplasm: Finally, in 2020, indirect evidence of the CD137+ T-cells power in determining a prolonged survival for cancer patients came from a study on melanoma patients where it was shown that TNFRSF9 low methylation levels and the subsequent increased mRNA expression at the tumor site, that was prevalently identified inside T-cells, correlated with a better OS of patients as well as a better PFS and response to the anti-PD-1 treatment [71].