Other putative STAT3 targets were DPYD, a gene encoding a key 5-FU-metabolizing enzyme [30], MUC1, which impacts on the response to radiotherapy in pancreatic cancer [31], and HIF1A, an established target of JAK-STAT signaling and previously reported as potential determinant of tumor radiosensitivity [32]. Here, MUC1 is linked to familial pancreatic carcinoma.