IFI16 and cytomegalovirus infection: Whereas the recruitment of IFI16 appears to activate the major immediate early promoter (MIEP) immediately upon HCMV infection, IFI16 displays a restrictive activity at later times as it suppresses expression of the HCMV DNA polymerase (UL54) and its processivity factor (UL44), which are required for viral DNA synthesis [62,63,64].