In the last year, mechanisms of SAMHD1 antagonization during herpesvirus infection were identified by several independent groups: conserved herpesvirus protein kinases from all beta- and gamma-herpesviruses (HHV-6/7 U69, HCMV UL97, EBV BGLF4 and KSHV ORF36) were shown to induce a strong phosphorylation of SAMHD1 thereby converting it to its inactive form [91,92]. Here, SAMHD1 is linked to Herpesviridae infectious disease.