EGFR and breast cancer: The dual-ligand NPs prepared by conjugating αvβ3 integrin-targeting peptide c (RGDfc) and EGFR-targeting peptide (YYHWYGYTPQNVI) with PEG-NH2 terminals of liposomal DSPE NPs using a sufo-SMCC cross-linker showed high cytotoxicity (IC50 value at 0.3 μM) when loaded with DOX against metastatic D2-A1 breast cancer cells expressing EGFR and αvβ3 integrin receptors.