Abbreviations: AMI = acute myocardial infarction, ATG16L1 = autophagy related 16 like 1, CAD = coronary artery disease, CAE = coronary artery ectasia, GWAS = genome-wide association studies, RAAS = renin angiotensin aldosterone system, SNPs = single nucleotide polymorphisms. The gene discussed is ATG16L1; the disease is myocardial infarction.