Abbreviations: ACE = angiotensin-converting enzyme 2, AHA/ASA = American Heart Association/American Stroke Association, BBB = blood-brain barrier, CNS = central nervous system, COVID-19 = coronavirus disease, CT = computed tomography, MCA = middle cerebral artery, NF-κB = Nuclear Factor-Kappa, NIHSS = National Institute of Health Stroke Scale, PCR = polymerase chain reaction, RAAS = Renin-Angiotensin-Aldosterone System, ROS = reactive oxygen species, SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2, STEMI = ST-elevation myocardial infarction, TNF = tumor necrosis factor. This evidence concerns the gene REN and Stroke.