INS and metabolic disease: Diabetes is a group of metabolic diseases characterized by chronic blood glucose (blood sugar) increase, with the characteristics of high disability, high mortality, and high complications.[1] The main cause of diabetes is the defect of insulin secretion in the body, which leads to insufficient insulin secretion or the secreted insulin has no biological effect on the receptor, which in turn leads to the disorder of protein, fat, carbohydrate, and other substances in the body.