PLA2G6 and Parkinsonism: The POLG variant was thus assigned as likely pathogenic according to the guidelines of the American College of Medical Genetics and Genomics.[9] The missense PLA2G6 variant (c.991G>T, p.Asp331Tyr) has been reported in Parkinsonism patients with an autosomal recessive inheritance pattern.[10] Thus, the PLA2G6 variant was considered less likely to be the causal gene in this case.