Abbreviations: DCR = disease control rate, DoR = duration of response, MET = mesenchymal-epithelial transition factor, NSCLC = non-small cell lung cancer, ORR = objective response rate, OS = overall survival, PD = progression disease, PD-L1 = programmed death ligand 1, PET-CT = positron emission tomography-computed tomography, PFS = progression-free survival, PR = partial regression, PSC = pulmonary sarcomatoid carcinoma, TKIs = tyrosine kinase inhibitors, TMB = tumor mutational burden. The gene discussed is CD274; the disease is neoplasm.