Estrogen can also be through combined with estrogen receptors on the surface of the liver cells to affect liver cell protein synthesis, causing bile reflux, leading to hepatic lobule cholestasis within.[20–22] Bile acid is released into the blood, the blood cholic acid concentration increased, deposited in the placental villi gap, thereby destroying the placental blood perfusion, resulting in the lack of fetal oxygen supply. Here, ESR1 is linked to cholestasis.