GATAD2B and Macrocephaly: Discussion: A recent study proposed that missense variants within GATAD2B CR domains disrupted assembly of nucleosome remodelling and deacetylase (NuRD) complex proteins, explaining the clinical overlap with other disorders associated with the NuRD complex (CHD3 and CHD4 genes) like hypotonia, intellectual disability, childhood apraxia of speech and macrocephaly (1).