VEGFA and neoplasm: Although inhibition of EC proliferation during tumor angiogenesis is a relevant strategy to starve tumors and decrease their progression, systemic VEGF inhibition also disturbs endothelial cell homeostasis and accelerates atherogenesis and arterial thrombembolic events often resulting in myocardial infarction, cerebrovascular insults, and peripheral or mesenteric ischemia [39–41] (Fig. 1).