A disintegrin and metalloproteinases (ADAMs) are involved in renal fibrosis and TGF‐β/Smad2/3 signaling upregulates Adam 10, 12, 17, 19 expression in renal cells and in unilateral ureteral obstruction models of renal fibrosis.35 This evidence concerns the gene TGFB1 and renal fibrosis.