Given the profound losses in GC-TFH cell number and function in Plasmodium-infected Il10-/- mice, and the known inhibitory effects of CD8 T cell-intrinsic IL-10 signaling during experimental Plasmodium infection [35], it was possible that CD4 T cell-intrinsic IL-10 signaling additionally supports step-wise TFH induction or acquisition of the GC-TFH program during experimental malaria. This evidence concerns the gene IL10 and malaria.