Altogether, these transcriptomic studies underscored the role of several genes in P. aeruginosa adaptation to the CF environment due to: (i) convergent expression in CF-adapted isolates in comparison to non-adapted ones, (ii) convergent expression in vivo in comparison to in vitro growth, and (iii) specific dysregulations in vivo in comparison to PAO1. Here, SMOX is linked to cystic fibrosis.