Children wheezing at first hospitalization and with at least one subsequent episode of asthma-like symptoms had higher nasal airway levels of type-2 cytokines (IL-13/IL-4), with no significant differences in other cytokines.31 Collectively, these data indicate that infants with wheezing at presentation have a higher probability for developing subsequent recurrent asthma-like symptoms with higher nasal airway levels of type-2 cytokines; therefore, suggesting a potential role of bronchodilators such as albuterol in treating their condition. This evidence concerns the gene IL4 and asthma.