Microarray study was used to analyse the altered protein profiling between carcinoma and para‐carcinoma tissues from Xuanwei area, and then, pathway enrichment was used to explore the interactions of these differential proteins and the present study showed pathways enriched in 5 processes including small cell lung cancer, ECM‐receptor interaction, focal adhesion, PI3K/AKT and amoebiasis. This evidence concerns the gene AKT1 and carcinoma.