Further experiments with overexpressed TXN2 or interfered with HP in lung cancer cell lines demonstrated that TXN2 overexpression and HP depletion promoted lung cancer resistance to erastin or RSL‐induced cell death were through attenuating ferroptosis, whereas upregulating of HP but downregulating TXN2 increased the ferroptosis rate of lung cancer cells. Here, TXN2 is linked to lung carcinoma.