Nonetheless, the effect of both erastin and RSL along with HP overexpression or TXN2 depletion on cell survival levels of Fe2+, MDA, intracellular lipid ROS, lipid peroxidation and GSH could be reversed by ferrostatin (Figure 7C‐G).Observation by TEM revealed that the lung cancer cells with interference of TXN2 or overexpression of HP had smaller mitochondria and a decreased number of mitochondrial cristae under the treatment of erastin or RSL, and the proportion of mitochondria with ruptured outer membrane increased in these cells (Figure 7I). This evidence concerns the gene TXN2 and lung cancer.