TXN2 and lung cancer: Then, we overexpressed HP or interfered with TXN2 in lung cancer cell lines; the protein level of HP and TXN2 was detected (Figure 7A); the mRNA level of HP overexpression and TXN2 depletion induced by erastin or RSL was also detected (Figure 7B); and results showed that erastin or RSL further eliminated TXN2 expression with TXN2 knockdown, whereas erastin or RSL further induced HP expression with HP overexpression.