Then, we overexpressed HP or interfered with TXN2 in lung cancer cell lines; the protein level of HP and TXN2 was detected (Figure 7A); the mRNA level of HP overexpression and TXN2 depletion induced by erastin or RSL was also detected (Figure 7B); and results showed that erastin or RSL further eliminated TXN2 expression with TXN2 knockdown, whereas erastin or RSL further induced HP expression with HP overexpression. Here, HP is linked to lung cancer.