Among the 11 cytokines tested (CCL2, EGF, MIF, TNF‐a, IFN‐γ, IL‐2, IL‐10, IL‐12/23 p40, VEGF‐A, MMP2, and MMP9), the four cytokines abundantly secreted by CAFs after coculture with CRC cells were CCL2, IL‐12/23 p40, VEGF‐A, and MMP2. This evidence concerns the gene TNF and colorectal carcinoma.