Indeed, Wang et al. showed that miR-130b is secreted from adipocytes during adipogenesis; its WAT mRNA expression is increased with obesity; its circulating abundance is elevated in human and murine obesity, correlates with BMI, and predicts the metabolic syndrome; and it is able to target muscle cells, supressing expression of its target gene, PGC-1α [282]. Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.