The results showed that the BMAL1 staining area and intensity in tumor tissue were reduced in the GL261 + BV2 (M2) Exosomes group (Fig. 8G), and by statistical analysis, the expression of BMAL1 protein in this group was reduced (P < 0.05, P < 0.001; Fig. 8H). Here, BMAL1 is linked to neoplasm.