CASR and Bartter syndrome with hypocalcemia: In Bartter-syndrome type V (OMIM: 601198), the constitutive activation of CaSR in the thick ascending limb inhibits the activity of the renal outer-medullary K channel and this results in renal salt wasting, hypocalcemia and hypomagnesemia as well as hyperreninaemic hyperaldosteronism and hypokalaemic alkalosis [15].