VEGFA and neoplasm: In patients undergoing primary surgery, we identified a significant increase of VEGF-A on tumor cells in WHO grade III meningiomas (mean ± SD or SEM) compared to WHO grade II meningiomas (unpaired t test: p = 0.0098, difference between means 11.48 ± 4.372, 95% confidence interval 2.822 to 20.13, Fig. 2a).