Comparing primary and recurrent tumors, there was a trend towards an increase of VEGF-A expression on tumor vessels in the third recurrence as compared to the primary situation (Fig. 3b), however significance was lost after Bonferroni correction A trend towards an increase was also observed for the receptor VEGFR-1 in the third recurrence compared to the primary situation (Fig. 3c), but once again significance was lost after the Bonferroni correction for multiple testing was applied. The gene discussed is VEGFA; the disease is neoplasm.