Comparing primary and recurrent tumors, there was a trend towards an increase of VEGF-A expression on tumor vessels in the third recurrence as compared to the primary situation (Fig. 3b), however significance was lost after Bonferroni correction A trend towards an increase was also observed for the receptor VEGFR-1 in the third recurrence compared to the primary situation (Fig. 3c), but once again significance was lost after the Bonferroni correction for multiple testing was applied. This evidence concerns the gene FLT1 and neoplasm.