In Saudi Arabian patients, HLA-DRB1*15:01, HLA-DQB1*06:02, and HLA-DQB1*06:01 have been shown to confer the highest risk to MS, with HLA-DRB1*15:01 showing an increased risk of previous relapses. The gene discussed is HLA-DQB1; the disease is myeloid sarcoma.