MYB and acute myeloid leukemia: Insofar as various forms of AML exhibit blockade of normal hematopoietic differentiation induced by distinct leukemia oncogenes, and at least some of the MYB-assembled cofactors have reduced gene expression in normal CD34+ hematopoietic progenitor cells (Figure 7C), we reasoned that their assembly in leukemia cells may be due to their aberrant co-expression.