EP300 and acute myeloid leukemia: Importantly, CRYBMIM binds CBP/P300 specifically, as exposure of AML cell extracts to streptavidin-immobilized biotinylated CRYBMIM leads to efficient binding to CBP/P300, but not MED15 which is highly expressed in MV411 AML cells and contains a known KIX domain with the closest sequence similarity to CBP/P300 (38% identity; Figure 2—figure supplement 1D–E).