To test this prediction, we carried out comparative gene expression analyses using RNA-sequencing of CRYBMIM effects in AML1-ETO-translocated Kasumi1, DNMTA3A;NPM1-mutant OCIAML3, MLL-rearranged MV411, NRAS-mutant;MYC-amplified HL60, and CALM10-rearranged U937 AML cell lines (Figure 5A–B and Figure 9—figure supplement 1). This evidence concerns the gene MYC and acute myeloid leukemia.