Development and investigation of clinical-grade MYB inhibitors, including improved derivatives of MYBMIM and CRYBMIM, are important directions of future work for patients with MYB-dependent acute myeloid and lymphoblastic leukemias, blastic plasmacytoid dendritic cell neoplasms, gliomas, breast, colon, and adenoid cystic carcinomas. The gene discussed is MYB; the disease is central nervous system cancer.