The physical association of MYB, CBFB, ZEB2, C/EBP family members, LYL1, SPI1, RUNX1, LMO2, and GFI1 and their non-redundant functional dependencies in AML cells (Figure 7A–D) are in agreement with the chromatin dynamics involving distinct MYB, C/EBP family members, LYL1, SPI1, and RUNX1 DNA-binding motifs observed in CRYBMIM-treated cells (Figure 6A–B), associated with the apparent redistribution and remodeling of their CBP/P300 co-activator complexes (Figure 6C–D). Here, SPI1 is linked to acute myeloid leukemia.