To define the composition of the MYB transcription factor complex across biologically and genetically distinct subtypes of AML, we used co-immunoprecipitation to measure the physical association of MYB and its cofactors in a panel of AML cell lines, spanning representative cell types with relatively high (MV411, HL60, OCIAML2, OCIAML3) and low (U937, Kasumi-1, K562) susceptibility to CRYBMIM (Figure 8). The gene discussed is MYB; the disease is acute myeloid leukemia.