MYB and acute myeloid leukemia: To confirm directly that peptidomimetic blockade of MYB:CBP/P300 releases CBP/P300 and promotes its association with alternative transcription factors, we specifically immunoprecipitated MYB and CBP/P300 from MV411 AML cells using respective antibodies, and determined their composition by western immunoblotting (Figure 12A–B).