This effect involves aberrantly organized MYB regulatory complexes, stably composed of additional transcription factors including LYL1, C/EBP family members, E2A, LMO2 and SATB1, that are reminiscent of core regulatory circuits observed in MYB-dependent T-cell lymphoblastic leukemias and other cancers (Mansour et al., 2014; Sanda et al., 2012). The gene discussed is LYL1; the disease is cancer.