LYL1 and leukemia: It will be important to determine how aberrant co-expression of such oncogenic regulatory complex co-factors is induced in leukemia cells by diverse oncogenes, such as for example by kinase-dependent dysregulation of transcription factor assembly recently described for MEF2C and LYL1 (Brown et al., 2018; Tarumoto et al., 2018; Vakoc and Kentsis, 2018).