This improved activity of CRYBMIM spanned diverse AML subtypes, including MLL-rearranged, AML1-ETO translocated, PML-RARA-translocated, DNMT3A-mutant, NPM1c-mutant, TP53-mutant, MYC-amplified, and WT1-mutant cell lines, with the exception of erythroblastic BCR-ABL1-translocated K562 cells (10 of 11 cell lines tested; Figure 3G and Supplementary file 1b). This evidence concerns the gene DNMT3A and acute myeloid leukemia.