It is possible that somatic mutations of regulatory DNA elements, such as those physically associated with MYB regulatory complexes, contribute to the aberrant assembly of these complexes on chromatin, as observed for the oncogenic TAL1 enhancer mutations in cases of T-ALL (Mansour et al., 2014), and recently suggested for other leukemias (He et al., 2019). This evidence concerns the gene MYB and acute lymphoblastic leukemia.