The major findings of the current study are the following: (1) female C57BL/6 J mice administered pristane develop hypertension, (2) mice administered pristane develop endothelial dysfunction in small high resistance arteries, and (3) pristane mice have variable renal injury, highlighted by glomerulosclerosis and immune cell infiltration but no changes in urinary albumin excretion or BUN. This evidence concerns the gene ALB and hypertensive disorder.