Second, we paid more attention to investigating the clinical significance and prospective molecular mechanisms of miRNA‐145‐5p in metastatic PCa; however, the biological functions of miRNA‐145‐5p and TOP2A in metastatic PCa and the relationship between miRNA‐145‐5p and TOP2A need to be further verified through both in vitro and in vivo experiments. This evidence concerns the gene TOP2A and posterior cortical atrophy.