In this analysis examining overweight and obese subjects with normal plasma LDL‐C separated based on median plasma PCSK9 per sex, we report that subjects with lower plasma PCSK9 identifying subjects with higher WAT‐surface LDLR and CD36 have (a) activation of WAT NLRP3 inflammasome measured as higher secretion of IL‐1β, higher plasma IL‐1Ra and lower WAT expression of pro‐IL‐1β; (b) higher risk factors for T2D assessed as lower WAT function, delayed postprandial plasma clearance of TGs and lower DI. This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.