However, the association of higher plasma apoB with WAT dysfunction and insulin resistance was strengthened by lower plasma PCSK9 (Wassef et al., 2015), suggesting a role for PCSK9‐regulated receptors, such as LDLR and CD36 (Demers et al., 2015; Schmidt et al., 2008) in metabolic dysfunction. Here, LDLR is linked to Insulin resistance.