A key sensor of metabolic stress in WAT that is implicated in the etiology of WAT dysfunction and T2D is the Nucleotide‐binding domain and Leucine‐rich repeat Receptor, containing a Pyrin domain 3 (NLRP3) inflammasome (Koenen et al., 2011; Skeldon et al., 2014; Stienstra et al., 2010; Vandanmagsar et al., 2011). The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.