VHL and von Hippel-Lindau disease: Investigations of the inherited von Hippel‐Lindau (VHL) clear cell RCC (ccRCC) predisposition syndrome led to the discovery of the VHL tumor suppressor gene and loss of function of this gene in VHL renal tumors, as well as in a significant percentage of tumors from patients with sporadic ccRCC (ranging from 59% to 92%).1, 2, 3, 4, 5