Among the key findings of the study, is the evidence of sex-specific transcriptional signatures in normal kidney tissues, affecting typical tumor suppressor genes escaping silencing, as well as other genes such as X-inactivation initiator XIST, singularly expressed from the inactive X and splicing factor ZRSR2, which has been notably associated with excess male risk in leukemia (9). The gene discussed is PSMB5; the disease is neoplasm.