Among the newly identified sex-dependent RCC prognosis markers in our study are ETV6, ANKRD47 and CRY2. Involved in the maintenance of the vascular network, ETV6 is historically known to be implicated in numerous chromosomal rearrangements in leukemia (49), and was recently established to promote migration and invasion in liver cancer (50). This evidence concerns the gene CRY2 and renal cell carcinoma.