NOX4 and cardiac hypertrophy: And in research of hypertrophic cardiomyopathy, it has been demonstrated that Fyn and NADPH oxidase 4 (NOX4) are co-located in the perinuclear region of cardiomyocytes, the N-terminal unique domain of Fyn phosphorylated tyrosine 566 in the C-terminus of NOX4 through their interaction and negatively regulated NOX4-induced exacerbation of pathological myocardial hypertrophy 83.