According to univariate analysis, cardiovascular disease, old age, WBC counts, low lymphocytes, high neutrophils, low eosinophils, NLR, MLR, hsCRP, procalcitonin, D-dimer, PTA, APTT, FIB, FDP, antibiotic therapy, use of corticosteroids, and use of thymosin alpha-1 were significantly correlated with the severity of COVID-19 (all P<0.05). This evidence concerns the gene PTMA and COVID-19.