The presence of significant liver fibrosis (F2-4) was associated with MAFLD, HBV DNA, ALT, AST, ALP, GGT, DBil, prealbumin, cholinesterase, globulin, total bile acid, TC, TG, LDL, urea, INR, and WBC, platelet, hemoglobin, neutrophil, and RBC counts. The gene discussed is GPT; the disease is Hepatic fibrosis.