The results here show significant respiratory diseases associated with likely pathologic variants, such as ABCA3:p.Val1399Met, MUC5B:p.Ile4979Thr, MUC5B:p.Gly5580Arg, MUC5B:p.Glu5621*, SCNN1B:p.Arg206Trp, SCNN1B:p.Glu468Lys, and SFTPA1:p.Gly98Ala. Here, ABCA3 is linked to respiratory system disorder.