ERBB2 and neoplasm: In our study, pCR rate of HER2 IHC 3+ tumours following anti-HER2 therapy was 52%, within the range reported in clinical trials with similar treatment regimens; for example, pCR rate was 38% in the NOAH trial using NACT with trastuzumab, 39% in the NeoSphere and 58% in the TRYPHAENA trials using NACT with trastuzumab and pertuzumab [10, 26, 27].