ERBB2 and breast cancer: Unlike nuclear Kaiso, the levels of cytoplasmic Kaiso in this cohort were significantly different based on hormone receptor (ER) status and breast cancer subtype, where the cytoplasmic levels of Kaiso were distinctly higher in the subtypes of breast cancer known to be more aggressive, including triple-negative breast cancer (TNBC), human epidermal growth factor receptor 2 positive (HER2+), and Luminal B (LumB) (Fig. 1c).