Given the close correlation between Kaiso and the LC3A/B autophagy-related proteins, we sought to further establish this relationship by employing a “bedside-to-bench” approach utilizing the human triple-negative breast cancer cell line, MDA-MB-231 depleted of Kaiso by RNA interference (RNAi) (Fig. 4a and Supplementary Fig. 6). Here, MAP1LC3A is linked to triple-negative breast carcinoma.