Given the observed influence of elevated levels of cytoplasmic and nuclear Kaiso on immune regulatory pathways (Fig. 6a, b), and the extensive potential role for secretory autophagy in the immune response43,44,46, we sought to define the linkage between LC3A/B, the subcellular distribution of Kaiso, and immune properties of the tumor microenvironment (Fig. 7). Here, MAP1LC3A is linked to neoplasm.