Interestingly, although the mRNA levels of Kaiso are highly predictive of poor breast cancer survival, as demonstrated in publicly available data sets (Fig. 1e); a direct comparison of available RNA-seq expression data, within a subset of this cohort (N = 134), demonstrates very little correlation between Kaiso mRNA and either nuclear Kaiso, cytoplasmic Kaiso, or their combined total (Fig. 1f). The gene discussed is ZBTB33; the disease is breast cancer.