Consistent with the observations in breast cancer cell lines, there is also significant cytoplasmic colocalization of Kaiso and LC3A/B in patient tumors with substantial variation by subtype (Fig. 5a, b) Thus, consistent with the co-enrichment of cytoplasmic Kaiso with LC3A/B in patient samples (Fig. 3a) and their colocalization in breast cancer cell lines (Fig. 4g), both proteins also show a substantial colocalization in patient tumors that varies by subtype (Fig. 5a, b). The gene discussed is ZBTB33; the disease is breast carcinoma.