Intriguingly, we detected a higher number of CD4+ T cells per CLL cell in LNs compared to paired blood samples (Supplementary Fig. 2G), and a significantly higher frequency of TR1-like cells in LNs (Fig. 1A), which moreover revealed a higher activation state based on CD69 and HLA-DR expression (Supplementary Fig. 2H). The gene discussed is CD4; the disease is B-cell chronic lymphocytic leukemia.