Unexpectedly and in contrast to these findings, our group has previously shown that the over-expression of fibroblast-growth-factor-receptor-1-IIIb (FGFR1-IIIb), associated with marked up-regulation of JNK activity, inhibits the malignant phenotype of pancreatic cancer cells [16]. This evidence concerns the gene MAPK8 and pancreatic neoplasm.