MAPT and dementia: Thus, although the current study findings were obtained in auditory cortex, they are likely to generalize across the cerebral cortex and provide a new conceptual framework for Sz as a “MAP2opathy.” That is, differential phosphorylation of MAP2, like its homolog tau in dementia pathogenesis, may mediate impairments of neuronal structure and function downstream of many different genetic (and possibly environmental) risk factors.